Treatment of Breast Cancer


Treatment of Breast Cancer
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against breast cancer metastasis. In this study, we examined the potential effect of thymoquinone (TQ), derived from the seeds of Nigella sativa, on the expression and regulation of CXCR4 in breast cancer cells. TQ was found to inhibit the expression of CXCR4 in MDA-MB-231 triple negative breast cancer (TNBC) cells in a dose- and time-dependent manner.
We also observed TQ (2 and 4 mg/kg) treatment significantly suppressed multiple lung, brain, and bone metastases in a dose-dependent manner in a metastasis breast cancer mouse model. Interestingly, H&E and immunohistochemical analysis of bone isolated from TQ treated mice indicated a reduction in number of osteolytic lesions and the expression of metastatic biomarkers. In conclusion, the results indicate that TQ primarily exerts its anti-metastatic effects by down-regulation of NF-κB regulated CXCR4 expression and thus has potential for the treatment of breast cancer.
https://www.ncbi.nlm.nih.gov/pubmed/30564115
https://www.ncbi.nlm.nih.gov/pubmed/?term=Black+Cumin+bacteria

Cancer Prevention
American Institute for Cancer Research recommendation compliance associated not only with cancer prevention and survival but less heart and respiratory disease mortality and a longer lifespan. Studies show by eating more Vegetables!

https://www.youtube.com/watch?v=nQ7GzDMEhgQ&feature=share

 

The nutrients in one 2 ounce packet of Soul is comparable to 8 to 10 servings of vegetables, 8 to 10 servings of fruits and 2 to 3 servings of healthy fats.
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Here are the 6 Patents for Black Cumin Seed that were granted:

Asthma/allergy Patent No EP1709995

To increase immune function US Patent No 5482711

Diabetes US Patent No 6042834

Inhibition of cancer cell growth US Patent No 5653981

Viral Infections US Patent No 6,841,174

Psoriasis US Patent No 6,531,164

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24 Apr 2020


By PubMed.org

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