Treatment of Breast Cancer
Treatment of Breast Cancer
Overexpression of chemokine receptor type 4 (CXCR4) has been found to be associated with increased cell proliferation, metastasis and also act as an indicator of poor prognosis in patients with breast cancer. Therefore, new agents that can abrogate CXCR4 expression have potential against breast cancer metastasis. In this study, we examined the potential effect of thymoquinone (TQ), derived from the seeds of Nigella sativa, on the expression and regulation of CXCR4 in breast cancer cells. TQ was found to inhibit the expression of CXCR4 in MDA-MB-231 triple negative breast cancer (TNBC) cells in a dose- and time-dependent manner.
We also observed TQ (2 and 4 mg/kg) treatment significantly suppressed multiple lung, brain, and bone metastases in a dose-dependent manner in a metastasis breast cancer mouse model. Interestingly, H&E and immunohistochemical analysis of bone isolated from TQ treated mice indicated a reduction in number of osteolytic lesions and the expression of metastatic biomarkers. In conclusion, the results indicate that TQ primarily exerts its anti-metastatic effects by down-regulation of NF-κB regulated CXCR4 expression and thus has potential for the treatment of breast cancer.
American Institute for Cancer Research recommendation compliance associated not only with cancer prevention and survival but less heart and respiratory disease mortality and a longer lifespan. Studies show by eating more Vegetables!
The nutrients in one 2 ounce packet of Soul is comparable to 8 to 10 servings of vegetables, 8 to 10 servings of fruits and 2 to 3 servings of healthy fats.
The 2 oz packet of SOUL is a blend of natural organic seeds oils that delivers the most potent wholesome food nutrients packed in a certified USA facility using unheated 'cold-pressed' technology. SOUL contains Omega 6 Sources of oils from Black Cumin Seeds, Black Raspberry Seeds, Chardonnay Grape Seeds, Resveratrol and D-ribose - the special blend of the 3 oils gives RAIN SOUL its power. Soul contains 10 servings of fruits, 10 servings of vegetables and 3 servings of healthy fatty acids.
SOUL has been hailed as one of the most important anti-aging supplements ever discovered. The amount of antioxidants in your body is directly proportional to how long you live. SOUL is certified organic unique antioxidant with essential fatty acids omega 3, 6, 9 vitamins, minerals, flavonoids and enzymes and 9 of the 14 super nutrients that is necessary to consume every day.
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Here are the 6 Patents for Black Cumin Seed that were granted:
Asthma/allergy Patent No EP1709995
To increase immune function US Patent No 5482711
Diabetes US Patent No 6042834
Inhibition of cancer cell growth US Patent No 5653981
Viral Infections US Patent No 6,841,174
Psoriasis US Patent No 6,531,164
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