The COVID-19 caused by a new type of coronavirus has emerged from China and led to thousands of deaths globally. Despite many groups engaged in studying the newly emerged virus and searching for the treatment, the understanding of the SARS-CoV2 target ligand interactions represents a key challenge. Several studies are being conducted to identify potential treatment. Alternatively, the results of numerous studies have shown that protease inhibitors can be a genuine leader in research. The antiviral activity and beneficial effect against respiratory disorders of thymoquinone have been largely demonstrated.
Thymoquinone (TQ) is one of the most active ingredients in Black Seed (Nigella sativa) seeds. The aim of this study is to testing In Silico the inhibition of the replication of SARS CoV2 by thymoquinone. This is a molecular simulation study using SARS CoV2 protease and thymoquinone structures provided by Protein Data Bank. The preliminary results have shown that thymoquinone may have inhibitory activities against SARS CoV2 protease. Furthermore, given the demonstrated results of thymoquinone, we can conclude that it may be considered as an effective or adjuvant treatment for SARS CoV2 infection.
Coronaviruses are responsible for several human diseases, such as the infectious novel coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Nigella sativa is a natural food supplement with a known safety profile that may provide a wealth of documented antiviral compounds.
At least 8 in silico studies have shown that some compounds of N sativa, including nigelledine, α-hederin, hederagenin, thymohydroquinone, and thymoquinone, had high to moderate affinity with SARS-CoV-2 enzymes and proteins. These compounds may potentially inhibit SARS-CoV-2 replication and attachment to host cell receptors.
Conclusions: These preliminary data of in silico studies propose N sativa as a potential phytotherapy candidate for COVID-19.
Further preclinical experimental evidence is required followed by a Phase I clinical trial.
Thymoquinone (TQ) is one of the most active ingredients in black seed (Nigella sativa).
SOUL contains the Best Omega 6 Sources of oils from Black Cumin Seed Oil Benefits, Black Raspberry Seed Oil, Chardonnay Grape Seed Oil, Resveratrol and D-Ribose Benefits- the special blend of the 3 oils gives RAIN SOUL its power. The nutrients in one 2 ounce packet is
comparable to 8 to 10 servings of vegetables, 8 to 10 servings of fruits and 2 to 3 servings of healthy fats.
The seeds are backed by over 200 scientific research studies with 6 worldwide patents for the black cumin seed.
Here are the 6 Patents for Black Cumin Seed that were granted:
Asthma/allergy Patent No EP1709995
To increase immune function US Patent No 5482711
Diabetes US Patent No 6042834
Inhibition of cancer cell growth US Patent No 5653981
Viral Infections US Patent No 6,841,174
Psoriasis US Patent No 6,531,164]
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